Questions designed for open responses, e.g., “comments”, were analysed by thematic analysis and qualitative content analysis. Questions designed for specific responses e.g., yes/no, were analysed quantitatively and presented as “number of participants”. Responses were taken exactly as they were written (or transcribed for phone questionnaires) for analysis. Participants were contacted primarily by email, but also via phone or post if email unavailable. Methods: Current or prospective research participants (dementia patients and healthy volunteers) were contacted with a questionnaire August-September 2020 and responses collated, transcribed and organised October-November 2020. We aimed to use information gathered to optimise study design alterations during the pandemic. We were particularly interested in preference for remote or in-person attendance and specific concerns about their own health and COVID-19 risk. Objectives: To determine the opinions of our participants on continuing contact and restarting research participation during the COVID-19 pandemic. To minimise the impact of the pandemic on our crucial research, we contacted our participants directly to glean their opinions on the impact of COVID-19 on research, and how our practices could be altered to continue safely during the pandemic. Sadly, many projects had to be suspended or terminated. At the Dementia Research Centre (DRC), in-person research visits were abandoned for all but clinically essential appointments to protect our staff and highly vulnerable patient groups. Lucianne Dobson, Floey Urban, Ross Paterson, Sebastian Crutch, Suzie Barker, Cath Mummery (Dementia Research Centre, National Hospital For Neurology And Neurosurgery, Queen Square, University College London And University College London Hospital - London (United Kingdom))īackground: The COVID-19 pandemic has had a significant impact on clinical trials on Alzheimer’s disease and other dementia research. AD CLINICAL TRIALS AND COVID-19 RP01- DEMENTIA RESEARCH PARTICIPATION AND PATIENT PREFERENCES DURING THE COVID-19 PANDEMIC.